Publication: Páginas de High endothelial venules and cell adhesion molecules in B cell chronic lymphocytic leukaemia and related low grade B-cell ...
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Date
1994
Authors
Csanaky, G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The high endothelial venule (HEV)-content
and the lymphocyte migration index (LMI) of reactive
lymph nodes and lymph nodes from patients with B-cell
chronic lymphocytic leukaemia (B-CLL), as well as
some related B-cell malignancies (lymphocytic
lymphoma -LL-, prolymphocytic leukaemia -PLL-) were
determined and statistically analyzed. The HEV-content
and the LMI were significantly higher in reactive lymph
nodes than in the low grade B-cell lymphomas and
leukaemias (p< 0.001). The number of HEVs among
lymphoma/leukaemia cases was the highest in LL
independently of the maturation. However, the
maturation of the process seems to determine the
intensity of lymphocyte migration; i.e. a significantly
higher LMI was found in mature (B-CLL, PF, mature; M
and LL, M) than in immature subtypes (B-CLL, PF,
immature -1M-, diffuse -D- and LL, IM) subtypes (levels
of significance varied from p< 0.05 to p< 0.001). Rased
on these findings, a more intense migration of
lymphocytes from blood to peripheral lymph nodes may
be supposed in LL than in B-CLL, thus explaining the
nodal sites of involvement in LL and the peripheral
blood in B-CLL. Within the same histological categories
the morphometric features in mature subtypes may
implicate an enhanced HEV-lymphocyte interaction
when compared to the immature subtypes.
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