Publication: Cardiac and pancreatic lesions in guinea pigs infected with encephalomyocarditis. EMC, virus
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Date
1991
Authors
Petruccelli, M.A. ; Hirasawa, K. ; Takeda, M. ; Itagaki, S. ; Doi, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cardiac and pancreatic lesions were observed
in guinea pigs infected with 2 variants (B and D) of
encephalornyocarditis (EMC) virus. Cardiac changes
were characterized by focal myocardial necrosis and
subsequent replacement by immature granulation tissue.
and the pancrcatic ones by vacuolar degeneration of
acinar cells. In the electron microscopic esaminatioiis.
tlie affected cardiornyocytes showed intracellular
oedema. swelling andlor partial destruction of mitochondria,
and distortion and disruption of myofihrils.
Intracellular vacuolization and dilatation of roughsurfaced
endoplasniic reticulurn (rER) were conspicuous
in the damaged pancreatic acinar cells. In addition,
intracisternal granules were found in dilated rER with a
high frequency. These changes were common to animals
infected with the B and D variants. On the contrary,
B cell alterations: i.e. degranulation and degeneration of
insulin granules, were detected only in animals infected
with the D variant.
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