Publication: Study of microvessel density
and the expression of the angiogenic
factors VEGF, bFGF and the receptors Flt-1 and FLK-1
in benign, premalignant and malignant prostate tissues
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Date
2006
Authors
Pallarés, J. ; Rojo, F. ; Iriarte, J. ; Morote, J. ; Armadans, L.I. ; De Torres, I.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Purpose: Vascular endothelial growth factor
(VEGF) is an angiogenic factor that stimulates
endothelial cell growth and enhances vascular
permeability. VEGF exerts its action by binding to the
specific cell surface receptors, fms-like tyrosine kinase 1
(Flt-1) and fetal liver kinase 1 (FLK/ KDR). In tumor
angiogenesis, Vascular endothelial growth factor
stimulates endothelial cells to produce Basic fibroblastic
growth factor (bFGF), which further enhances
angiogenic activity. Very little information on the
expression of VEGF, bFGF, and the receptors Flt-1 and
FLK/KDR is available. Herein, we evaluate the
expression of these angiogenic factors and receptors in
normal prostate, high grade prostate intraepithelial
neoplasia (HGPIN) and prostatic cancer (CaP). Materials
and Methods: 58 selected surgical specimens exhibiting
areas of normal prostate, HGPIN, and CaP were
evaluated for microvessel density, and for VEGF, bFGF,
Flt-1 and FLK/KDR protein expression by
immunohistochemistry. Results were correlated with
pathological data. Results: There was a statistically
significant increase in the microvessel density and in the
expression of the angiogenic factors VEGF, bFGF and
the receptors FLK/KDR and Flt-1, in the premalignant
and malignant tissues in comparison with normal
prostatic glands. Microvessel density also correlated
with higher Gleason grade, pathological stage and the
expression of the receptors FLK/KDR and Flt-1.
Conclusions: The “initiation switch” of angiogenesis
was observed to be an early event consistent with the
recruitment of new vasculature into high grade PIN
lesions and it increased in the progression of prostatic cancer.
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