Publication: TGF-B1 and VEGF after fresh frozen bone allograft insertion in oral-maxillo-facial surgery
Loading...
Date
2010
Authors
Rodella, L.F. ; Favero, G. ; Boninsegna, R. ; Borgonovo, A. ; Rezzani, R. ; Santoro, F.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Bone regeneration technique using allografts
is widely used in oral surgery to repair alveolar defects
and to increase alveolar volume for endosseous implant
insertions. Bone allografts promote the reabsorption and
neo-synthesis of bone tissue, which are regulated by
numerous cytokines, proteins and growth factors. In this
study, six patients with insufficient alveolar volume for
endosseous implant insertions, were treated with bone
regeneration technique using Fresh Frozen Bone (FFB)
allografts collected from the femoral head or the hip.
Samples of bone graft collected during graft
insertion surgery and biopsies collected six months later
during implantology were fixed, decalcified and
analyzed histomorphologically and morphometrically by
haematoxylin-eosin staining. In addition, TGF-ß1 and
VEGF were analyzed by immunohistochemistry.
The histological analysis of FFBs showed wide areas
of calcified bone organized in osteons intermingled with
areas of non-calcified matrix containing osteoblasts.
However, the regenerated alveolar bone, collected six
months after the graft insertion surgery, showed wide
areas of non-calcified matrix. TGF-ß1 and VEGF were
less expressed in FFB than in regenerated alveolar bone
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.