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Diagnostic utility of CD205 in breast cancer: Simultaneous detection of myoepithelial cells and dendritic cells in breast tissue by CD205

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dc.contributor.authorOhe, Rintaro
dc.contributor.authorAung, Naing Ye
dc.contributor.authorTamura, Yuka
dc.contributor.authorKabasawa, Takanobu
dc.contributor.authorUtsunomiya, Aya
dc.contributor.authorTamazawa, Nobuyuki
dc.contributor.authorKitaoka, Takumi
dc.contributor.authorMeng, Hong-Xue
dc.contributor.authorShibata, Kenichi
dc.contributor.authorYamakawa, Mitsunori
dc.date.accessioned2022-11-21T16:20:54Z
dc.date.available2022-11-21T16:20:54Z
dc.date.issued2020
dc.description.abstractBackground. CD205 can be used to detect myoepithelial cells (MECs) and dendritic cells (DCs) in breast tissue. However, the usefulness of CD205 immunostaining in the pathological diagnosis of breast tumors is not fully understood. The objective of this study was to re-evaluate CD205 co-expression with other MEC markers, such as p63 and CD10, in nonneoplastic and neoplastic breast tissue and to evaluate its pathological diagnostic utility in these types of breast cancer. Material and methods. Nonneoplastic breast tissue samples with a terminal duct lobular unit and duct were obtained from fibroadenoma and mastopathy patients. Neoplastic breast tissue samples included ductal carcinoma in situ (DCIS) (n=43) and invasive ductal carcinoma (IDC) (n=60), including the tubule-forming type (n=20). These specimens were investigated by CD205, p63, and CD10 immunostaining. Results. In addition to p63 and CD10, CD205 was expressed on MECs in nonneoplastic breast and DCIS tissue samples; CD205 was simultaneously detected on DCs that had infiltrated DCIS and IDC tumor nests. CD205 was expressed on cancer cells themselves in only 7.3% of the breast cancer samples. The number of intratumoral CD205 + DCs in tubular IDC was significantly higher than that in DCIS (P<0.01)es
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dc.format.extent8es
dc.identifier.citationHistology and Histopathology Vol. 35, nº5 (2020)
dc.identifier.doihttps://doi.org/10.14670/HH-18-164
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/125791
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCD205es
dc.subjectMyoepithelial celles
dc.subjectDendritic celles
dc.subjectBreast tissuees
dc.subjectPathological diagnosises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleDiagnostic utility of CD205 in breast cancer: Simultaneous detection of myoepithelial cells and dendritic cells in breast tissue by CD205es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.35, nº5 (2020)