Publication: The impact of mechanical stress on stem cell properties: The link between cell shape and pluripotency
Authors
Caifeng Ho, Jolene ; Ueda, Jun ; Shimizu, Takeshi
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
10.14670/HH-11-665
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info:eu-repo/semantics/article
Description
Abstract
y. Embryonic development and differentiation
are controlled largely by external stimuli. Mechanical
forces, such as those exerted by the surrounding cells
and tissues, gravity and substrate rigidity, have been
shown to affect cell morphology and spreading, thus
triggering signaling pathways that dictate their
development. These mechanosignaling pathways play
important roles in cellular differentiation and the
determination of cell fate. In this review, we discuss the
effects of external environmental stimuli on cell
differentiation and how this affects pluripotency, as well
as the key molecules and pathways involved in
mechanosignaling, particularly in relation to embryonic
stem cells. Advances in experimental techniques and
devices used to study the different aspects of
mechanobiology are also examined. Finally, the effects
of mechanical stress on the initiation and maintenance of
pathological processes such as cancer, as well as their
implications for prognosis and possible therapies, are
discussed.
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Citation
Histology and Histopathology, vol. 31, nÂş 1, (2016)
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