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Divergences in KIR2D+ natural killer and KIR2D+CD8+ T-cell reconstitution following liver transplantation

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dc.contributor.authorLópez Álvarez, M.R.
dc.contributor.authorCampillo, J.A.
dc.contributor.authorBlanco García, R.M.
dc.contributor.authorSalgado Cecilia, G.
dc.contributor.authorBolarín, J.M.
dc.contributor.authorGil, J.
dc.contributor.authorGarcía Alonso, A.M.
dc.contributor.authorMuro, M.
dc.contributor.authorÁlvarez López, M.R.
dc.contributor.authorMiras, M.
dc.contributor.authorMinguela, A.
dc.contributor.authorGimeno Arias, Lourdes
dc.contributor.authorLegaz Pérez, Isabel
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-07-12T08:21:12Z
dc.date.available2024-07-12T08:21:12Z
dc.date.issued2011-03
dc.description© 2011 American Society for Histocompatibility and Immunogenetics. This document is the Published version of a Published Work that appeared in final form in Human Immunology. To access the final edited and published work see https://doi.org/10.1016/j.humimm.2010.12.015
dc.description.abstractNatural killer (NK) and CD8+ T cells may be active elements in the allograft response, but little is known about their role in liver transplantation. Some of these cells express killer immunoglobulin-like receptors (KIRs), which after binding specific ligands may transmit inhibitory/activating signals. In this study, circulating NK and CD8+ T cells expressing CD158a/h (KIR2DL1/S1) or CD158b/j (KIR2DL2/3/S2) receptors were analyzed in 142 liver recipients by flow cytometry. They were underrepresented in patients before transplantation, but following transplantation, whereas the KIR2D+ NK subsets experienced a late recuperation (day 365) mainly in C2-homozygous patients developing early acute rejection, recovery of the 2 CD8+KIR2D+ T cells started earlier, showing significant differences on day 365 between patients without acute rejection and those suffering from it (p = 0.004 and p < 0.0001, respectively). These differences were also evident when the human leukocute antigen-C genotypes of the recipient were considered. In conclusion, whereas the late recovery of KIR2D+ NK cells in C2/C2 patients appears to be linked to acute rejection, the increase in early CD8+KIR2D+ T cells in overall liver recipients correlates with a most successful early graft outcome. Therefore, monitoring of KIR2D+ cells appears to be a useful tool for liver transplant follow-up.es
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dc.format.extent9es
dc.identifier.citationHuman Immunology, 2011, Vol. 72, Issue 3, pp. 229-237
dc.identifier.doihttps://doi.org/10.1016/j.humimm.2010.12.015
dc.identifier.issnPrint: 0198-8859
dc.identifier.urihttp://hdl.handle.net/10201/143025
dc.languageenges
dc.publisherElsevier
dc.relationThis work was supported by the CIBERehd program and 07/1224 and 10/01964 projects from the Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Ministerio de Sanidad y Consumo, Spain, and Caja Murcia (2008–2010) aid, and by Fundación Séneca, Murcia, Spain (Project 04087/GERM/06 ). The research work of María Rocío López-Álvarez was financed by the CIBERehd Program.es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0198885910005781#aep-acknowledgment-id21
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectNK cellses
dc.subjectCD8 T lymphocyteses
dc.subjectKIR2D receptorses
dc.subjectLiver transplantationes
dc.subjectTolerancees
dc.titleDivergences in KIR2D+ natural killer and KIR2D+CD8+ T-cell reconstitution following liver transplantationes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationa0170301-b64f-46f8-810a-ff18c9bf0a5f
relation.isAuthorOfPublicationb83b4b59-2d61-40f0-9108-5c6a6d158295
relation.isAuthorOfPublication.latestForDiscoverya0170301-b64f-46f8-810a-ff18c9bf0a5f
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