Publication: Divergences in KIR2D+ natural killer and KIR2D+CD8+ T-cell reconstitution following liver transplantation
Authors
López Álvarez, M.R. ; Campillo, J.A. ; Blanco García, R.M. ; Salgado Cecilia, G. ; Bolarín, J.M. ; Gil, J. ; García Alonso, A.M. ; Muro, M. ; Álvarez López, M.R. ; Miras, M. ; Minguela, A. ; Gimeno Arias, Lourdes ; Legaz Pérez, Isabel
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Publisher
Elsevier
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DOI
https://doi.org/10.1016/j.humimm.2010.12.015
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info:eu-repo/semantics/article
Description
© 2011 American Society for Histocompatibility and Immunogenetics. This document is the Published version of a Published Work that appeared in final form in Human Immunology. To access the final edited and published work see https://doi.org/10.1016/j.humimm.2010.12.015
Abstract
Natural killer (NK) and CD8+ T cells may be active elements in the allograft response, but little is known about their role in liver transplantation. Some of these cells express killer immunoglobulin-like receptors (KIRs), which after binding specific ligands may transmit inhibitory/activating signals. In this study, circulating NK and CD8+ T cells expressing CD158a/h (KIR2DL1/S1) or CD158b/j (KIR2DL2/3/S2) receptors were analyzed in 142 liver recipients by flow cytometry. They were underrepresented in patients before transplantation, but following transplantation, whereas the KIR2D+ NK subsets experienced a late recuperation (day 365) mainly in C2-homozygous patients developing early acute rejection, recovery of the 2 CD8+KIR2D+ T cells started earlier, showing significant differences on day 365 between patients without acute rejection and those suffering from it (p = 0.004 and p < 0.0001, respectively). These differences were also evident when the human leukocute antigen-C genotypes of the recipient were considered. In conclusion, whereas the late recovery of KIR2D+ NK cells in C2/C2 patients appears to be linked to acute rejection, the increase in early CD8+KIR2D+ T cells in overall liver recipients correlates with a most successful early graft outcome. Therefore, monitoring of KIR2D+ cells appears to be a useful tool for liver transplant follow-up.
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Citation
Human Immunology, 2011, Vol. 72, Issue 3, pp. 229-237
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