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The possible role of colligin, HSP47, a collagen-binding protein, in the pathogenesis of human and experimental fibrotic diseases

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dc.contributor.authorRazzaque, M.S.es
dc.contributor.authorTaguchi, T.es
dc.date.accessioned2011-02-22T11:09:54Z
dc.date.available2011-02-22T11:09:54Z
dc.date.issued1999
dc.description.abstractColligin or heat shock protein 47 (HSP47) is a stress protein that resides in the endoplasmic reticulum and is thought to participate in intracellular processing, folding, assembly and secretion of procollagens. Irrespective of the tissue site and organ, induction of colliginlHSP47 expression is always noted during the process of fibrosis, particularly in and around the fibrotic lesions in both humans and experimental models. Its expression is highly tissue- and cell-specific, and restricted to mostly phenotypically altered collagenproducing cells. These observations suggest that upregulation of this collagen-specific chaperone-colliginl HSP47 may play an important role in the subsequent fibrotic process, possibly by regulating increased synthesis/assembly of collagens.es
dc.formatapplication/pdfes
dc.format.extent14es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19235
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCollagenes
dc.subjectGlomerulosclerosises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleThe possible role of colligin, HSP47, a collagen-binding protein, in the pathogenesis of human and experimental fibrotic diseaseses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.14, nº 4 (1999)