Publication: The possible role of colligin, HSP47, a collagen-binding protein, in the pathogenesis of human and experimental fibrotic diseases
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Date
1999
Authors
Razzaque, M.S. ; Taguchi, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Colligin or heat shock protein 47 (HSP47) is
a stress protein that resides in the endoplasmic reticulum
and is thought to participate in intracellular processing,
folding, assembly and secretion of procollagens.
Irrespective of the tissue site and organ, induction of
colliginlHSP47 expression is always noted during the
process of fibrosis, particularly in and around the fibrotic
lesions in both humans and experimental models. Its
expression is highly tissue- and cell-specific, and
restricted to mostly phenotypically altered collagenproducing
cells. These observations suggest that upregulation
of this collagen-specific chaperone-colliginl
HSP47 may play an important role in the subsequent
fibrotic process, possibly by regulating increased
synthesis/assembly of collagens.
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