Knocked out by Rho Rac T-cell biology

Publication:
Knocked out by Rho Rac T-cell biology

dc.contributor.author	Bustelo, X.R.	es
dc.date.accessioned	2011-05-11T10:58:46Z
dc.date.available	2011-05-11T10:58:46Z
dc.date.issued	2002
dc.description.abstract	The Rho/Rac family is a group of Ras-related proteins with demonstrated roles in the regulation of proliferation and cytoskeletal structures in a number of cell lineages. Despite this, the actual role of these proteins in T-cells could not be addressed in vivo due to the lack of adequate animal models. Recently, the use of knockout and transgenic animals for Rac1, Rac2, and RhoA has provided a genetic proof of the importance of Rho/Rac protein in different aspects of T-cell signaling. These animals have also allowed us to get better views about the influence of these GTPases proteins on the maturation decisions of immature lymphocytes and on the signaling strategies these GTPases utilize to favor the generation of coherent and robust immune responses.	es
dc.format	application/pdf	es
dc.format.extent	5	es
dc.identifier.issn	0213-3911	es
dc.identifier.uri	http://hdl.handle.net/10201/20830
dc.language	eng	es
dc.publisher	Murcia : F. Hernández	es
dc.relation.ispartof	Histology and histopathology	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.subject	T cell maturation	es
dc.subject	T cell signaling	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina	es
dc.title	Knocked out by Rho Rac T-cell biology	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es

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