Publication: Knocked out by Rho Rac T-cell biology
Authors
Bustelo, X.R.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The Rho/Rac family is a group of Ras-related
proteins with demonstrated roles in the regulation of
proliferation and cytoskeletal structures in a number of
cell lineages. Despite this, the actual role of these
proteins in T-cells could not be addressed in vivo due to
the lack of adequate animal models. Recently, the use of
knockout and transgenic animals for Rac1, Rac2, and
RhoA has provided a genetic proof of the importance of
Rho/Rac protein in different aspects of T-cell signaling.
These animals have also allowed us to get better views
about the influence of these GTPases proteins on the
maturation decisions of immature lymphocytes and on
the signaling strategies these GTPases utilize to favor the
generation of coherent and robust immune responses.
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