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Hepatocyte nuclear factor-1B(HNF-1B) in human urogenital organs, Its expression and role in embryogenesis and tumorigenesis

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dc.contributor.authorKato, Norikoes
dc.contributor.authorMotoyama, Teiichies
dc.date.accessioned2014-01-09T10:37:32Z
dc.date.available2014-01-09T10:37:32Z
dc.date.issued2009
dc.description.abstractMolecules responsible for embryogenesis are often involved in tumorigenesis. Recent exhaustive cDNA microarray analyses in human neoplasms expanded knowledge of such molecules. Hepatocyte nuclear factor-1ß (HNF-1ß) is a homeobox transcription factor that functions as a homodimer or heterodimer with HNF-1a. In contrast to HNF-1a, HNF-1ß is very weakly expressed in the liver and is commonly expressed in the kidneys. During human embryonic stage, HNF-1ß plays an important role in organogenesis, especially of the urogenital system. In the human fetus, HNF-1ß expression is common in mesonephric duct derivatives and metanephros (permanent kidneys). HNF-1ß germline mutations cause malformations of these structures. Recent microarray analyses have disclosed that HNF-1ß is aberrantly up-regulated in clear cell carcinoma of the ovary, which is a carcinoma of müllerian nature, but which was initially misnamed “mesonephroma”. HNF-1ß is also expressed in ovarian endometriosis, which is a probable origin of clear cell carcinoma. On the other hand, HNF-1ß is downregulated in renal neoplasms, such as chromophobe cell carcinoma. In this review, we first summarize HNF-1ß expression in the developing urogenital system of the human embryo. Then, we describe the HNF-1ß status in human urogenital neoplasms and discuss its role in tumorigenesis.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/37547
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectUrogenital organses
dc.subjectEmbryogenesises
dc.subject.other616.6 - Patología del sistema genitourinarioes
dc.titleHepatocyte nuclear factor-1B(HNF-1B) in human urogenital organs, Its expression and role in embryogenesis and tumorigenesises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.24,nº11 (2009)