Publication: Hepatocyte nuclear factor-1B(HNF-1B) in human urogenital organs, Its expression and role in embryogenesis and tumorigenesis
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Date
2009
Authors
Kato, Noriko ; Motoyama, Teiichi
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Molecules responsible for embryogenesis are
often involved in tumorigenesis. Recent exhaustive
cDNA microarray analyses in human neoplasms
expanded knowledge of such molecules. Hepatocyte
nuclear factor-1ß (HNF-1ß) is a homeobox transcription
factor that functions as a homodimer or heterodimer with
HNF-1a. In contrast to HNF-1a, HNF-1ß is very weakly
expressed in the liver and is commonly expressed in the
kidneys. During human embryonic stage, HNF-1ß plays
an important role in organogenesis, especially of the
urogenital system. In the human fetus, HNF-1ß
expression is common in mesonephric duct derivatives
and metanephros (permanent kidneys). HNF-1ß
germline mutations cause malformations of these
structures. Recent microarray analyses have disclosed
that HNF-1ß is aberrantly up-regulated in clear cell
carcinoma of the ovary, which is a carcinoma of
müllerian nature, but which was initially misnamed
“mesonephroma”. HNF-1ß is also expressed in ovarian
endometriosis, which is a probable origin of clear cell
carcinoma. On the other hand, HNF-1ß is downregulated
in renal neoplasms, such as chromophobe cell
carcinoma. In this review, we first summarize HNF-1ß
expression in the developing urogenital system of the
human embryo. Then, we describe the HNF-1ß status in
human urogenital neoplasms and discuss its role in
tumorigenesis.
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