Publication: Growth factors and remyelination in the CNS
Authors
Woodruff, R.H. ; Franklin, R.J.M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
It is now well established that there is an
inherent capacity within the central nervous system
(CNS) to remyelinate areas of white matter that have
undergone demyelination. However this repair process is
not universally consistent or sustained, and persistent
demyelination occurs in a number of situations, most
notably in the chronic multiple sclerosis (MS) plaque.
Thus there is a need to investigate ways in which myelin
deficits within the CNS rnay be restored. One approach
to this problem is to investigate ways in which the
inherent remyelinating capacity of the CNS rnay be
stimulated to remyelinate areas of long-term demyelination.
The expression of growth factors, which
are known to be involved in developmental myelinogenesis,
in areas of demyelination strongly suggests that
they are involved in spontaneous remyelination.
Therefore delivery of exogenous growth factors into
areas of persistent demyelination is a potential
therapeutic strategy for stimulating remyelination. This
review will discuss the evidence that growth factors rnay
have a role in promoting CNS remyelination by
enhancing the survival and stimulating the proliferation
and recruitment of remyelinating oligodendrocytes.
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