Publication: Expression of intermediate filaments and other special markers by testicular germ cell tumors. With reference to embryogenesis
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Date
1992
Authors
Hanai, J. ; Lin, M. ; Wada, A. ; Ishiguro, S. ; Miki, T. ; Sakaguchi, H. ; Kanda, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Distribution of intermediate filament proteins
(IFs) and severa1 special markers was studied in 39
testicular germ cell tumors and 8 embryos and foetuses.
The similarity and difference between development
of germ cell tumor and embryogenesis were
immunohistochemically investigated. Seminoma and
embryonal carcinoma, as tumoral counterparts of
undifferentiated germ cells, were characterized by little
IF expression. This study revealed that the maturing and
differentiating process in germ cell tumor is different
from normal embryonal development and the tumor cells
showed leaping maturing steps in tumorigenesis.
Immunostaining for IFs helped to discover the further
differentiation occurring in embryonal carcinoma and to
demonstrate heterogeneous elements in non-seminoma
germ cell tumors, which sometimes might not be
apparent by light microscopical observation of H&E
staining section. According to the findings, two patterns
in mixed germ cell tumors are suggested; Le., combined
and diffuse types. The mechanism of tumorigenesis of
the two types is supposed to be different. Clinically, the
prognosis of most patients with testicular germ cell
tumor is fairly good because of the improved
chemotherapies that are dependent on histological
diagnosis.
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