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Ovarian serous carcinogenesis from tubal secretory cells

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dc.contributor.authorZhang, Wenjing
dc.contributor.authorWei, Linxuan
dc.contributor.authorLi, Lingmin
dc.contributor.authorYang, Binlie
dc.contributor.authorKong, Beihua
dc.contributor.authorYao, Guang
dc.contributor.authorZheng, Wenxin
dc.coverage.spatial, ,es
dc.date.accessioned2021-02-10T11:38:13Z
dc.date.available2021-02-10T11:38:13Z
dc.date.issued2015
dc.description.abstractDue to a poor understanding of tumorigenesis, ovarian cancers remain the most lethal gynecologic malignancy and cause horrific deaths. In the last decade, a new dualistic model for ovarian cancer was proposed, wherein ovarian serous cancers are classified as either high-grade or low-grade, with each having different tumorigenic processes, and pathologic and clinical features. Surprisingly, both high- and lowgrade ovarian serous cancers were recently found to originate not in the ovaries, but rather from the secretory cells of the fallopian tube, mostly from the tubal fimbriated ends. In this article, we review the evidentiary basis for the aforementioned paradigm shift in the cell origin of ovarian serous cancers, as well as its potential clinical implicationses
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.citationHistology and Histopathology, vol. 30, nÂş 11, (2015)
dc.identifier.doi10.14670/HH-11-64510.14670/HH-11-645
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/103021
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectOvarian serous carcinomaes
dc.subjectSecretory celles
dc.subjectFallopian tubees
dc.subjectLGSCes
dc.subjectHGSCes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleOvarian serous carcinogenesis from tubal secretory cellses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.30,nÂş11 (2015)