Publication:
Ovarian serous carcinogenesis from tubal secretory cells

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Zhang-30-1295-1302-2015.pdf(7.77 MB)
Date
2015
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Authors
Zhang, Wenjing ; Wei, Linxuan ; Li, Lingmin ; Yang, Binlie ; Kong, Beihua ; Yao, Guang ; Zheng, Wenxin
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Publisher
Universidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­a
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DOI
10.14670/HH-11-64510.14670/HH-11-645
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info:eu-repo/semantics/article
Description
Abstract
Due to a poor understanding of tumorigenesis, ovarian cancers remain the most lethal gynecologic malignancy and cause horrific deaths. In the last decade, a new dualistic model for ovarian cancer was proposed, wherein ovarian serous cancers are classified as either high-grade or low-grade, with each having different tumorigenic processes, and pathologic and clinical features. Surprisingly, both high- and lowgrade ovarian serous cancers were recently found to originate not in the ovaries, but rather from the secretory cells of the fallopian tube, mostly from the tubal fimbriated ends. In this article, we review the evidentiary basis for the aforementioned paradigm shift in the cell origin of ovarian serous cancers, as well as its potential clinical implications
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Ovarian serous carcinoma , Secretory cell , Fallopian tube , LGSC , HGSC
Citation
Histology and Histopathology, vol. 30, nÂş 11, (2015)
URI
http://hdl.handle.net/10201/103021
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Histology and histopathology Vol.30,nÂş11 (2015)
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