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A twist tale of cancer metastasis and tumor angiogenesis

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dc.contributor.authorTseng, Jen-Chieh
dc.contributor.authorChen, Hsiao-Fan
dc.contributor.authorWu, Kou-Juey
dc.date.accessioned2021-02-10T11:18:25Z
dc.date.available2021-02-10T11:18:25Z
dc.date.issued2015
dc.description.abstractTwist1 is an evolutionally conserved transcription factor. Originally identified in Drosophila as a key regulator for mesoderm development, it was later implicated in many human diseases, including Saethre-Chotzen syndrome and cancer. Twist1’s involvement in cancer has been well recognized. Driven by hypoxia-induced factor-1 (HIF-1), Twist1 has been considered as a proto-oncogene and its overexpression has been observed in a wide variety of human cancers. High expression level of Twist1 is closely related to tumor aggressiveness and metastatic potential. In cancer cells, Twist1 has been shown to function as a key regulator of epithelial-mesenchymal transition (EMT), a critical process for metastasis initiation. Twist1 has also been implicated in maintaining cancer stemness for selfrenewal and chemoresistance. This review first summarizes the roles of Twist1 in embryo development and Saethre-Chotzen syndrome followed by a discussion of Twist1’s critical functions in cancer. In particular, the review focuses on the recent discovery of Twist1’s capability to promote endothelial transdifferentiation of cancer cells beyond EMT.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.citationHistology and Histopathology, vol. 30, nº 11, (2015)
dc.identifier.doi10.14670/HH-11-638
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/103003
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectTwist1es
dc.subjectEMTes
dc.subjectCancer stem celles
dc.subjectAngiogenesises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleA twist tale of cancer metastasis and tumor angiogenesises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.30,nº11 (2015)