Publication: A twist tale of cancer metastasis and tumor angiogenesis
Authors
Tseng, Jen-Chieh ; Chen, Hsiao-Fan ; Wu, Kou-Juey
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
10.14670/HH-11-638
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info:eu-repo/semantics/article
Description
Abstract
Twist1 is an evolutionally conserved
transcription factor. Originally identified in Drosophila
as a key regulator for mesoderm development, it was
later implicated in many human diseases, including
Saethre-Chotzen syndrome and cancer. Twist1’s
involvement in cancer has been well recognized. Driven
by hypoxia-induced factor-1 (HIF-1), Twist1 has been
considered as a proto-oncogene and its overexpression
has been observed in a wide variety of human cancers.
High expression level of Twist1 is closely related to
tumor aggressiveness and metastatic potential. In cancer
cells, Twist1 has been shown to function as a key
regulator of epithelial-mesenchymal transition (EMT), a
critical process for metastasis initiation. Twist1 has also
been implicated in maintaining cancer stemness for selfrenewal and chemoresistance. This review first
summarizes the roles of Twist1 in embryo development
and Saethre-Chotzen syndrome followed by a discussion
of Twist1’s critical functions in cancer. In particular, the
review focuses on the recent discovery of Twist1’s
capability to promote endothelial transdifferentiation of
cancer cells beyond EMT.
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Citation
Histology and Histopathology, vol. 30, nº 11, (2015)
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