Publication: MicroRNA in prostate cancer: Practical aspects
Authors
Patil, Pallavi A. ; Magi-Galluzzi, Cristina
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
10.14670/HH-11-647
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info:eu-repo/semantics/article
Description
Abstract
In the last decade, microRNAs (miRNAs)
have emerged as biomarkers for cancer diagnosis,
prognosis, therapy and prediction of treatment response
and have earned a promising role in prostate cancer
(PCa) management. A plethora of studies have been
conducted on miRNA expression in PCa compared to
non-neoplastic prostatic tissue, in PCa of different
histologic grades and pathologic stages, in castration
resistance prostate cancer (CRPC), in metastatic disease
and in response to therapy, with evidence pointing
towards distinctive miRNAs differentially expressed in
each of these phases. In addition to tissue, MiRNA can
be detected in blood, serum, and urine. The aim of this
review is to survey studies conducted on human prostate
tissue and biofluids and to consolidate trustworthy data
on the role of miRNA in the occurrence and progression
of PCa, with a delineation of differentially expressed
miRNAs and an analysis of their association with PCa
prognosis, progression to CRPC and metastatic disease,
as well as their correlation with response to
chemotherapy and hormonal therapy. Changes in
circulating miRNAs may represent potentially useful
non-invasive biomarkers for PCa diagnosis, staging and
prediction of outcome.
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Citation
Histology and Histopathology, vol. 30, nº 12, (2015)
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