Publication: In vitro and in vivo characterization of neural stem cells
Authors
Bazán, E. ; Alonso, F.J.M. ; Redondo, C. ; López-Toledano, M.A. ; Alfaro, J.M. ; Reimers, D. ; Herranz, A. S. ; Paíno, C.L. ; Serrano, A.B. ; Cobacho, N. ; Caso, E. ; Lobo, M.V.T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Neural stem cells are defined as clonogenic
cells with self-renewal capacity and the ability to
generate all neural lineages (multipotentiality). Cells
with these characteristics have been isolated from the
embryonic and adult central nervous system. Under
specific conditions, these cells can differentiate into
neurons, glia, and non-neural cell types, or proliferate in
long-term cultures as cell clusters termed
“neurospheres”. These cultures represent a useful model
for neurodevelopmental studies and a potential cell
source for cell replacement therapy. Because no specific
markers are available to unequivocally identify neural
stem cells, their functional characteristics (self-renewal
and multipotentiality) provide the main features for their
identification. Here, we review the experimental and
ultrastructural studies aimed at identifying the
morphological characteristics and the antigenic markers
of neural stem cells for their in vitro and in vivo
identification.
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