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Mesenchymal stem cells: from the perivascular environment to clinical applications

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dc.contributor.authorVezzani, Bianca
dc.contributor.authorPierantozzi, Enrico
dc.contributor.authorSorrentino, Vincenzo
dc.date.accessioned2022-05-31T07:35:43Z
dc.date.available2022-05-31T07:35:43Z
dc.date.issued2018
dc.description.abstractAdult stem cells represent a fundamental biological system that has fascinated scientists over the last decades, and are currently the subject of a large number of studies aimed at better defining the properties of these cells, with a prominent focus on improving their application in regenerative medicine. One of the most used adult stem cells in clinical trials are mesenchymal stem cells (MSCs), which are multipotent cells able to differentiate into mature cells of mesodermal lineages. Following the initial studies on MSCs isolated from bone marrow, similar cells were also isolated from a variety of fetal and adult human tissues. Initially considered as identical and equipotent, MSCs from tissues other than bone marrow actually display differences in terms of their plastic abilities, which can be ascribed to the tissue of origin and/or to the procedures used for their isolation. Moreover, results from additional studies suggest that cultured MSCs represent the in vitro version of a subset of in vivo resident cells localized in the perivascular environment. In this review, we will focus our attention on MSCs from tissues other than bone marrow, their in vivo localization and their current applications in clinics.es
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dc.format.extent12es
dc.identifier.citationHistology and Histopathology, Vol.33, nÂş12, (2018)
dc.identifier.doiDOI: 10.14670/HH-11-998
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/120670
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMesenchymal stem cellses
dc.subjectPerivascular environmentes
dc.subjectPericyteses
dc.subjectPerivascular cellses
dc.subjectRegenerative medicinees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleMesenchymal stem cells: from the perivascular environment to clinical applicationses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.33,nÂş12 (2018)