Publication: Mesenchymal stem cells: from the perivascular environment to clinical applications
Authors
Vezzani, Bianca ; Pierantozzi, Enrico ; Sorrentino, Vincenzo
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI: 10.14670/HH-11-998
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info:eu-repo/semantics/article
Description
Abstract
Adult stem cells represent a fundamental
biological system that has fascinated scientists over the
last decades, and are currently the subject of a large
number of studies aimed at better defining the properties
of these cells, with a prominent focus on improving their
application in regenerative medicine. One of the most
used adult stem cells in clinical trials are mesenchymal
stem cells (MSCs), which are multipotent cells able to
differentiate into mature cells of mesodermal lineages.
Following the initial studies on MSCs isolated from
bone marrow, similar cells were also isolated from a
variety of fetal and adult human tissues. Initially
considered as identical and equipotent, MSCs from
tissues other than bone marrow actually display
differences in terms of their plastic abilities, which can
be ascribed to the tissue of origin and/or to the
procedures used for their isolation. Moreover, results
from additional studies suggest that cultured MSCs
represent the in vitro version of a subset of in vivo
resident cells localized in the perivascular environment.
In this review, we will focus our attention on MSCs from
tissues other than bone marrow, their in vivo localization
and their current applications in clinics.
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Citation
Histology and Histopathology, Vol.33, nÂş12, (2018)
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