Publication: Interstitial collagen in alcoholic human liver
Authors
Stenbäck, F. ; Wasenius, Veli-Matti ; Sotaniemi, Eero A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The occurrence and intensity of staining for
specific antibodies against the aminoterminal propeptide
of type 111 procollagen (PIIIP), which is indicative of the
synthesis and the degradation of that collagen type, was
studied in sections from normal and alcoholic livers and
compared with serum PIIIP levels, serum antipyrine
clearance, fibronectin distribution and morphology as
revealed by conventional stains and electronmicroscopy.
Positive staining for PIIIP and fibronectin was observed
in the perisinusoidal space of the normal liver and in
portal tracts. In alcohol-induced fatty liver positive
staining increased around the central veins, in alcoholic
hepatitis increased staining reaction was seen to a limited
extent in areas of cell injury. Extensive reticulin and
PIIIP-positive areas were found in the periportal
interstitium of the cirrhotic livers and in large fibrotic
areas extending into the surrounding parenchyma in
cases of active disease. The results show a distinct
relationship between collagen type 111 metabolism,
morphologically detectable hepatic injury and liver cell
function tests, with tissue deposition occurring later in
the disease process than biochemically detectable serum
collagen levels and signs of altered liver cell function.
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