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Changes in the peptidergic innervation in the carotid body of rats chronically exposed to hypercapnic hypoxia: an effect of arterial CO2 tension

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dc.contributor.authorKusakabe, T.es
dc.contributor.authorHirakawa, H.es
dc.contributor.authorMatsuda, H.
dc.contributor.authorYamamoto, Y.
dc.contributor.authorNagai, T.
dc.contributor.authorKawakami, T.
dc.contributor.authorTakenaka, T.
dc.contributor.authorHayashida, Y.
dc.date.accessioned2011-05-11T10:57:37Z
dc.date.available2011-05-11T10:57:37Z
dc.date.issued2002
dc.description.abstractThe abundance of neuropeptide Y (NPY)-, vasoactive intestinal polypeptide (VIP)-, substance P (SP)-, and calcitonin gene-related peptide (CGRP)- immunoreactive nerve fibers in the carotid body was examined in chronically hypercapnic hypoxic rats (10% O2 and 6-7% CO2 for 3 months), and the distribution and abundance of these four peptidergic fibers were compared with those of previously reported hypocapnicand isocapnic hypoxic carotid bodies to evaluate the e ffect of arterial CO2 tension. The vasculature in the carotid body of chronically hypercapnic hypoxic rats was found to be enlarged in comparison with that of normoxic control rats, but the rate of vascular e n l a rgement was smaller than that in the previously reported hypocapnic- and isocapnic hypoxic carotid bodies. In the chronically hypercapnic hypoxic carotid b o d y, the density per unit area of parenchymal NPY fibers was significantly increased, and that of VIP fibers was unchanged, although the density of NPY and VIP fibers in the previously reportetd chronically hypocapnic and isocapnic hypoxic carotid bodies was opposite to that in hypercapnic hypoxia as observed in this study. The density of SP and CGRP fibers was decreased. These results along with previous reports suggest that d i fferent levels of arterial CO2 tension change the p e p t i d e rgic innervation in the carotid body during chronically hypoxic exposure, and altered peptiderg i c innervation of the chronically hypercapnic hypoxic carotid body is one feature of hypoxic adaptation.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/20752
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCarotid bodyes
dc.subjectImmunohistochemistryes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleChanges in the peptidergic innervation in the carotid body of rats chronically exposed to hypercapnic hypoxia: an effect of arterial CO2 tensiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.17, nº 1 (2002)