Publication: Changes in the peptidergic innervation
in the carotid body of rats chronically exposed to
hypercapnic hypoxia: an effect of arterial CO2 tension
Authors
Kusakabe, T. ; Hirakawa, H. ; Matsuda, H. ; Yamamoto, Y. ; Nagai, T. ; Kawakami, T. ; Takenaka, T. ; Hayashida, Y.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The abundance of neuropeptide Y (NPY)-,
vasoactive intestinal polypeptide (VIP)-, substance P
(SP)-, and calcitonin gene-related peptide (CGRP)-
immunoreactive nerve fibers in the carotid body was
examined in chronically hypercapnic hypoxic rats (10%
O2 and 6-7% CO2 for 3 months), and the distribution and
abundance of these four peptidergic fibers were
compared with those of previously reported hypocapnicand
isocapnic hypoxic carotid bodies to evaluate the
e ffect of arterial CO2 tension. The vasculature in the
carotid body of chronically hypercapnic hypoxic rats
was found to be enlarged in comparison with that of
normoxic control rats, but the rate of vascular
e n l a rgement was smaller than that in the previously
reported hypocapnic- and isocapnic hypoxic carotid
bodies. In the chronically hypercapnic hypoxic carotid
b o d y, the density per unit area of parenchymal NPY
fibers was significantly increased, and that of VIP fibers
was unchanged, although the density of NPY and VIP
fibers in the previously reportetd chronically hypocapnic
and isocapnic hypoxic carotid bodies was opposite to
that in hypercapnic hypoxia as observed in this study.
The density of SP and CGRP fibers was decreased.
These results along with previous reports suggest that
d i fferent levels of arterial CO2 tension change the
p e p t i d e rgic innervation in the carotid body during
chronically hypoxic exposure, and altered peptiderg i c
innervation of the chronically hypercapnic hypoxic
carotid body is one feature of hypoxic adaptation.
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