Publication: Ultrastructural relations between nigrostriatal dopaminergic neurons and cholinergic nerve endings in the human brain
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Date
1993
Authors
Anglade, P. ; Tsuji, S. ; Hirsch, E.C. ; Javoy-Agid, F. ; Agid, Y.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The connections between cholinergic nerve
endings anct nigrostriatal dopaminergic neurons were
s t ~ ~ d i ei nd the substantia nigra pars compacta of the
human brain. Irnmunocytochemistry of tyrosine
hydroxylase followed by ionic fixation of acetylcholinelike
cation i l l synaptic vesicles allowed dopaminergic
neurons and cholinergic nerve endings to be visualized
on the same ultrathin section. Numerous contacts, some
of them with synaptic structures, were observed between
nerve endings, with or without precipitates of
acetylcholine-like cation and dendrites or cell bodies of
tyrosine hydroxylase-inimunoreactive neurons. These
results, which agree with previous studies performed in
the rat. suggest that cholinergic nerve endings control the
activity of the nigrostriatal neurons at the level of the
dendrites and cell bodies in the substantia nigra.
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Citation
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