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Colocalization of tumor necrosis factor-alpha and nitric oxide-synthase immunoreactivity in mast cell granules of nasal mucosa

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dc.contributor.authorBacci, S.es
dc.contributor.authorRucci, L.es
dc.contributor.authorRiccardi-Arbi, R.
dc.contributor.authorBorghi-Cirri, M.B.
dc.date.accessioned2011-02-22T10:59:36Z
dc.date.available2011-02-22T10:59:36Z
dc.date.issued1998
dc.description.abstractWe have demonstrated, with immunohistochemical techniques, the colocalization of tumour necrosis factor-a (TNFa) with a constitutive neuronal isoform of nitric oxide-synthase (NOS) in granules of the majority (52.77%) of the mast cells (MCs) of healthy human nasal mucosa. Very few cells were positive for NOS alone (2.54%). Some cells were positive for TNFa alone (16.73%) or negative for both antigens (18%). Since dim degranulation occurs in MCs of healthy nasal mucosa at any time, we propose that low concentrations of TNFa and NOS secreted by these cells are involved not only in the regulation of homeostasis of normal human nasal mucosa, but also in the survival and function of MCs themselves.es
dc.formatapplication/pdfes
dc.format.extent4es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19111
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMast cellses
dc.subjectNasal mucosaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleColocalization of tumor necrosis factor-alpha and nitric oxide-synthase immunoreactivity in mast cell granules of nasal mucosaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.13, nº 4 (1998)