Publication: Colocalization of tumor necrosis factor-alpha and nitric oxide-synthase immunoreactivity in mast cell granules of nasal mucosa
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Date
1998
Authors
Bacci, S. ; Rucci, L. ; Riccardi-Arbi, R. ; Borghi-Cirri, M.B.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We have demonstrated, with immunohistochemical
techniques, the colocalization of tumour
necrosis factor-a (TNFa) with a constitutive neuronal
isoform of nitric oxide-synthase (NOS) in granules of
the majority (52.77%) of the mast cells (MCs) of healthy
human nasal mucosa. Very few cells were positive for
NOS alone (2.54%). Some cells were positive for TNFa
alone (16.73%) or negative for both antigens (18%).
Since dim degranulation occurs in MCs of healthy nasal
mucosa at any time, we propose that low concentrations
of TNFa and NOS secreted by these cells are involved
not only in the regulation of homeostasis of normal
human nasal mucosa, but also in the survival and
function of MCs themselves.
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