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The ARF-p53 senescence pathway in mouse and human cells

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dc.contributor.authorWadhwa, R.es
dc.contributor.authorSugahara, T.es
dc.contributor.authorTaira, K.
dc.contributor.authorKaul, S.C.
dc.date.accessioned2011-06-08T09:04:54Z
dc.date.available2011-06-08T09:04:54Z
dc.date.issued2004
dc.description.abstractMouse and human cells have most frequently been used for studies that have led to the elucidation of various molecular pathways involved in senescence. The ARF–p53 pathway has been assigned as one of the major protagonists in these phenomena. ARF is an alternative reading frame protein encoded along with p16INK4A by the INK4a locus on human chromosome 9p21 and the corresponding locus on mouse chromosome 4. Whereas the mouse ARF (p19ARF) consists of 169 amino acids, the human ARF (p14ARF) consists of 132 amino acids, truncated at the C-terminus. Molecular studies on the regulation of ARF activity by its binding partners have revealed that mouse ARF protein, but not human ARF protein, interacts with a cytoplasmic protein, Pex19p. This interaction of mouse ARF with Pex19p results in its milder p53 activation function in mouse cells as compared to human cells and thus accounts, at least in part, for the weaker tumor surveillance and frequent immortalization of mouse cells.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/21541
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectp53es
dc.subjectSenescencees
dc.subjectRegulation
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleThe ARF-p53 senescence pathway in mouse and human cellses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.19, nº 1 (2004)