Publication: The ARF-p53 senescence pathway in mouse and human cells
Authors
Wadhwa, R. ; Sugahara, T. ; Taira, K. ; Kaul, S.C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Mouse and human cells have most frequently
been used for studies that have led to the elucidation of
various molecular pathways involved in senescence. The
ARF–p53 pathway has been assigned as one of the
major protagonists in these phenomena. ARF is an
alternative reading frame protein encoded along with
p16INK4A by the INK4a locus on human chromosome
9p21 and the corresponding locus on mouse
chromosome 4. Whereas the mouse ARF (p19ARF)
consists of 169 amino acids, the human ARF (p14ARF)
consists of 132 amino acids, truncated at the C-terminus.
Molecular studies on the regulation of ARF activity by
its binding partners have revealed that mouse ARF
protein, but not human ARF protein, interacts with a
cytoplasmic protein, Pex19p. This interaction of mouse
ARF with Pex19p results in its milder p53 activation
function in mouse cells as compared to human cells and
thus accounts, at least in part, for the weaker tumor
surveillance and frequent immortalization of mouse
cells.
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