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Thyrotropin-releasing hormone receptor expression in thyroid follicular cells: a new paracrine role of C-cells?

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dc.contributor.authorDe Miguel, M.es
dc.contributor.authorFernández-Santos, J.M.es
dc.contributor.authorUtrilla, J.C.
dc.contributor.authorCarrillo-Vico, A.
dc.contributor.authorBorrero, J.
dc.contributor.authorConde, E.
dc.contributor.authorGuerrero, J.M.
dc.contributor.authorMartín Lacave, Inés
dc.date.accessioned2011-06-30T12:00:34Z
dc.date.available2011-06-30T12:00:34Z
dc.date.issued2005
dc.description.abstractThyrotropin-releasing hormone (TRH) synthesized in the hypothalamus has the capability of inducing the release of thyroid-stimulating hormone (TSH) from the anterior pituitary, which in turn stimulates the production of thyroid hormones in the thyroid gland. Immunoreactivity for TRH and TRH-like peptides has been found in some tissues outside the nervous system, including thyroid. It has been demonstrated that thyroid C-cells express authentic TRH, affecting thyroid hormone secretion by follicular cells. Therefore, C-cells could have a paracrine role in thyroid homeostasis. If this hypothesis is true, follicular cells should express TRH receptors (TRH-Rs) for the paracrine modulation carried out by C-cells. In order to elucidate whether or not C-cell TRH production could act over follicular cells modulating thyroid function, we studied TRH-Rs expression in PC C13 follicular cells from rat thyroid, by means of immunofluorescence technique and RT-PCR analysis. We also investigated the possibility that C-cells present TRH-Rs for the autocrine control of its own TRH production. Our results showed consistent expression for both receptors, TRH-R1 and TRH-R2, in 6-23 C-cells, and only for TRH-R2 in PC C13 follicular cells. Our data provide new evidence for a novel intrathyroidal regulatory pathway of thyroid hormone secretion via paracrine/autocrine TRH signaling.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/22498
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectRat thyroides
dc.subjectFollicular cellses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleThyrotropin-releasing hormone receptor expression in thyroid follicular cells: a new paracrine role of C-cells?es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.20, nº 3 (2005)