Publication: Thyrotropin-releasing hormone receptor expression in
thyroid follicular cells: a new paracrine role of C-cells?
Authors
De Miguel, M. ; Fernández-Santos, J.M. ; Utrilla, J.C. ; Carrillo-Vico, A. ; Borrero, J. ; Conde, E. ; Guerrero, J.M. ; Martín Lacave, Inés
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Thyrotropin-releasing hormone (TRH)
synthesized in the hypothalamus has the capability of
inducing the release of thyroid-stimulating hormone
(TSH) from the anterior pituitary, which in turn
stimulates the production of thyroid hormones in the
thyroid gland. Immunoreactivity for TRH and TRH-like
peptides has been found in some tissues outside the
nervous system, including thyroid. It has been
demonstrated that thyroid C-cells express authentic
TRH, affecting thyroid hormone secretion by follicular
cells. Therefore, C-cells could have a paracrine role in
thyroid homeostasis. If this hypothesis is true, follicular
cells should express TRH receptors (TRH-Rs) for the
paracrine modulation carried out by C-cells. In order to
elucidate whether or not C-cell TRH production could
act over follicular cells modulating thyroid function, we
studied TRH-Rs expression in PC C13 follicular cells
from rat thyroid, by means of immunofluorescence
technique and RT-PCR analysis. We also investigated the
possibility that C-cells present TRH-Rs for the autocrine
control of its own TRH production. Our results showed
consistent expression for both receptors, TRH-R1 and
TRH-R2, in 6-23 C-cells, and only for TRH-R2 in PC
C13 follicular cells. Our data provide new evidence for a
novel intrathyroidal regulatory pathway of thyroid
hormone secretion via paracrine/autocrine TRH
signaling.
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