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Involvement of µ-protocadherin in colorectal carcinogenesis: a promise for clinico-pathological evaluation

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dc.contributor.authorLosi, Lorena
dc.contributor.authorGrande, Alexis
dc.date.accessioned2018-12-12T12:25:30Z
dc.date.available2018-12-12T12:25:30Z
dc.date.issued2014
dc.description.abstractSummary. Cell-cell adhesion is a fundamental activity to allow the maintenance of epithelial integrity, and defects impairing this process promote the formation of tumors such as colorectal cancer (CRC). In this regard, a crucial role is played by adhesion molecules, named cadherins, which exert their function through the inhibition of the ß-catenin signaling proliferation pathway, constitutively activated in CRC. A number of reports, published over the last decade, have highlighted the existence of a novel cadherin family member, called µ-protocadherin, to underline the hybrid nature of its extra-cellular region, including both cadherin-like and mucin-like domains. Is has been shown that this protein plays an important role in inter-cellular adhesion processes, inhibits ß-catenin activity in normal colorectal mucosa, undergoes a down-regulated expression in CRC and is up-regulated upon treatmes
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.citationHistol Histopathol, vol. 29, nº 1, (2014)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/65300
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectµ-protocadherines
dc.subjectMUCDHLes
dc.subjectß-catenines
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleInvolvement of µ-protocadherin in colorectal carcinogenesis: a promise for clinico-pathological evaluationes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.29, nº 1 (2014)