Publication: Involvement of µ-protocadherin
in colorectal carcinogenesis: a promise
for clinico-pathological evaluation
Authors
Losi, Lorena ; Grande, Alexis
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Summary. Cell-cell adhesion is a fundamental activity
to allow the maintenance of epithelial integrity, and
defects impairing this process promote the formation of
tumors such as colorectal cancer (CRC). In this regard, a
crucial role is played by adhesion molecules, named
cadherins, which exert their function through the
inhibition of the ß-catenin signaling proliferation
pathway, constitutively activated in CRC. A number of
reports, published over the last decade, have highlighted
the existence of a novel cadherin family member, called
µ-protocadherin, to underline the hybrid nature of its
extra-cellular region, including both cadherin-like and
mucin-like domains. Is has been shown that this protein
plays an important role in inter-cellular adhesion
processes, inhibits ß-catenin activity in normal colorectal
mucosa, undergoes a down-regulated expression in CRC
and is up-regulated upon treatm
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Citation
Histol Histopathol, vol. 29, nº 1, (2014)
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