Publication: Distribution of the carcinoembryonic antigen CEA
in gastric lesions. lmmunohistochemical testing
of three novel monoclonal antibodies
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Date
1990
Authors
Berner, Aasmund ; Bormer, Ole ; Marton, Per F. ; Nesland, Jahn M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Three mouse monoclonal antibodies MAB
(CEA 12-140-1, -2 and -4) raised against different CEA
epitopes were tested in 32 gastric adenocarcinomas (18
intestinal type and 14 diffuse type) and 34 gastric lesions
with severe and moderate dysplasia. The MAB stained
1 3 , l l and 13 out of the 14 diffuse carcinomas and 11,13
and 13 out of the 18 intestinal carcinomas. The dysplastic
lesions were positive in 9, 9 and 6 out of 34 cases. Less
than half of the cases with metaplastic epithelium adjacent
to the carcinomas were also positive for MAB. All
MAB showed the same pattern of reactivity without
cross-reactivity. Their cumulative staining rate corresponded
closely to that of polyclonal CEA antiserum, but
the MAB stained more cells. The reactivity was confined
to intracytoplasmic vacuoles in diffuse carcinomas and
appeared diffusely in the cytoplasm or limited to the cell
membrane in intestinal type of carcinomas. Our findings
do not indicate CEA to be a reliable marker for malignant
transformation in gastric mucosa.
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