Publication: Endogenous sex hormone and estrogen binding
activity in thyroid cancer
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Date
1989
Authors
Imai, Yutaka ; Yamakawa, Mitsunori ; Matsuda, Mikio ; Takeshi, Kasajima
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Summary. The reactions of four anti-sex hormone
(Estrone, Estradiol, Estriol and Testosterone) antisera
were immunohistochemically examined in 109 cancerous
and 80 normal and benign thyroid tissues. Four kinds of
sex hormones were detected in the tumour cells of 61
cases (56%) of thyroid cancer and in the follicular epithelial
cells of 4 cases (5%) of normal and benign thyroid tissues.
Among the thyroid cancers, 54 female (61%) and 7 cases
in males (33%) were positive for sex hormones. Furthermore,
estrogen binding activity was screened histochemically
in 36 thyroid tissues of various types, and detected
not only in thyroid cancer (6115 cases), but in normal and
benign thyroid tissues (3121 cases) as well. It was concluded
that endogenous estradiol was located in thyroid cancers
more frequently in females than in males and that there
was estrogen binding activity in the cells of not only
thyroid cancers, but also normal and benign thyroid
tissues. This is the first report of the dernonstration of
endogenous sex hormones in thyroid cancer.
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