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Overview of joint tissue alterations in femoroacetabular impingement: What we know through laboratory analyses

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dc.contributor.authorMichela Battistelli
dc.contributor.authorEleonora Olivotto
dc.contributor.authorGiorgia Borciani
dc.contributor.departmentBiología Celular e Histología
dc.contributor.editorUniversidad de Murcia, Departamento de Biologia Celular e Histiologia
dc.date.accessioned2026-05-13T08:36:18Z
dc.date.available2026-05-13T08:36:18Z
dc.date.issued2026
dc.description.abstractHip osteoarthritis (HOA) is the most common hip joint disorder, accounting for approximately 27.9% of all cases of osteoarthritis (OA), often leading to total hip replacement (THR). In the last decades, femoroacetabular impingement (FAI) has been addressed as a significant etiological factor in the development of early-onset HOA, especially in young adults with non-dysplastic hips. FAI has been found to cause damage to all joint tissues, cartilage, labrum, and subchondral bone, thus underlining the importance of an early diagnosis and intervention to prevent progression to end-stage disease. This review aims to provide a comprehensive overview of the biochemical, morphological, and cellular alterations occurring in hip joint tissues in the presence of FAI. Understanding the early pathological changes is of crucial importance as they often precede radiographic signs of disease and may serve as valuable biomarkers for early detection and management of FAI and peri-arthritic conditions to delay or prevent the need for THR in younger populations.
dc.formatapplication/pdf
dc.format.extent16
dc.identifier.doihttps://doi.org/10.14670/HH-25-019
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/231681
dc.languageeng
dc.relationSin financiación externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectFemoroacetabular impingement
dc.subjectAcetabular labrum
dc.subjectCartilage
dc.subjectBone, Intra-articular tissues,
dc.subjectLaboratory techniques
dc.subjectHip joint
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleOverview of joint tissue alterations in femoroacetabular impingement: What we know through laboratory analyses
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
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Histology and histopathology, Vol.41, Nº6, (2026)