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Changes in the number and distribution of Langerhans cells in the hydantoin hyperplasic gingiva as compared with the clinically normal one

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dc.contributor.authorIbañez, P.es
dc.contributor.authorSagredo, E.es
dc.contributor.authorPino, A.
dc.date.accessioned2011-02-01T08:45:09Z
dc.date.available2011-02-01T08:45:09Z
dc.date.issued1990
dc.description.abstractA study was made of the number of Langerhan's cells (LCs) per mm2 of section which express the antigens T, and/or HLA-DR in seriated gingival sections of diphenylhydantoine-induced hyperplasia (HG) and clinically normal gingivae (NG). NG showed histological correlation with its macroscopic appearance. In HG the classical histopathological findings were verified, as well as the epithelial maturation irregularities, conducive to the development of epithelial gaps. In the immunostained samples, LCs appear amply distributed in the epithelium in greater numbers than in NG and more branched except in the immature areas, where they mostly express HLA-DR. In HG keratinocytes, HLA-DR' are observed in the basal layer, except in developing epithelial gap zones. The Wilcoxon test for the NG-T6lNG-DR and HG-T,/HGDR was not significant; but the Mann Whitney test for NG-TdHG-T, and NG-DWHG-DR was significant to p < 0.05. It is understood that the increase in LC numbers in HG is a manifestation of their active participation in local immune reactions. The presence of DR+/T,- LCs in the less keratinized areas seems to indicate the relationship of LCs with epithelial proliferation and/or differentiation.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18196
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectGingivaes
dc.subjectHydantoines
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleChanges in the number and distribution of Langerhans cells in the hydantoin hyperplasic gingiva as compared with the clinically normal onees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 5, nº 4 (1990)