Publication: Changes in the number and distribution of Langerhans cells in the hydantoin hyperplasic gingiva as compared with the clinically normal one
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Date
1990
Authors
Ibañez, P. ; Sagredo, E. ; Pino, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
A study was made of the number of
Langerhan's cells (LCs) per mm2 of section which
express the antigens T, and/or HLA-DR in seriated
gingival sections of diphenylhydantoine-induced
hyperplasia (HG) and clinically normal gingivae (NG).
NG showed histological correlation with its macroscopic
appearance. In HG the classical histopathological
findings were verified, as well as the epithelial
maturation irregularities, conducive to the development
of epithelial gaps. In the immunostained samples, LCs
appear amply distributed in the epithelium in greater
numbers than in NG and more branched except in the
immature areas, where they mostly express HLA-DR. In
HG keratinocytes, HLA-DR' are observed in the basal
layer, except in developing epithelial gap zones. The
Wilcoxon test for the NG-T6lNG-DR and HG-T,/HGDR
was not significant; but the Mann Whitney test for
NG-TdHG-T, and NG-DWHG-DR was significant to
p < 0.05. It is understood that the increase in LC
numbers in HG is a manifestation of their active
participation in local immune reactions. The presence of
DR+/T,- LCs in the less keratinized areas seems to
indicate the relationship of LCs with epithelial
proliferation and/or differentiation.
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