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The level of phosphorylated Akt predominantly reflects the expressive status of CerbB2 in invasive breast cancer

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dc.contributor.authorChi, Yingkai
dc.contributor.authorZhao, Jing
dc.contributor.authorCui, Su-Ping
dc.contributor.authorJiang, Ping
dc.contributor.authorWang, Jian-ping
dc.contributor.authorZhang, Hong
dc.contributor.authorMao, Jing-Zhuo
dc.contributor.authorLiu, Hai-Jing Liu
dc.contributor.authorHou, Lin
dc.contributor.authorZhang, Bo
dc.date.accessioned2018-05-11T15:43:01Z
dc.date.available2018-05-11T15:43:01Z
dc.date.issued2013
dc.description.abstractAlthough some evidence has been documented on EGFR/PI3K mediation of Akt activation in breast cancers, ILK and DNA-PK have not been investigated so far. The aim of this study was to analyze the expression of phosphorylated Akt (pAkt) in breast cancer, with respect to its upstream regulators. The immunostaining of pAkt (Ser473) in 70 invasive breast cancers revealed that status of CerbB2 could play a major role in Akt phosphorylation, while ILK was also involved in the stimulated level of pAkt. The results would provide an important clue for the activation of Akt and potential targeted therapy in breast cancer.es
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dc.format.extent7es
dc.identifier.citationHistology and histopathology, Vol. 28, n.º 5 (2013)
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/58339
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectpAktes
dc.subjectCerbB2es
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleThe level of phosphorylated Akt predominantly reflects the expressive status of CerbB2 in invasive breast canceres
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.28, nº 5 (2013)