Publication: The level of phosphorylated Akt
predominantly reflects the expressive
status of CerbB2 in invasive breast cancer
Authors
Chi, Yingkai ; Zhao, Jing ; Cui, Su-Ping ; Jiang, Ping ; Wang, Jian-ping ; Zhang, Hong ; Mao, Jing-Zhuo ; Liu, Hai-Jing Liu ; Hou, Lin ; Zhang, Bo
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Although some evidence has been
documented on EGFR/PI3K mediation of Akt activation
in breast cancers, ILK and DNA-PK have not been
investigated so far. The aim of this study was to analyze
the expression of phosphorylated Akt (pAkt) in breast
cancer, with respect to its upstream regulators. The
immunostaining of pAkt (Ser473) in 70 invasive breast
cancers revealed that status of CerbB2 could play a
major role in Akt phosphorylation, while ILK was also
involved in the stimulated level of pAkt. The results
would provide an important clue for the activation of
Akt and potential targeted therapy in breast cancer.
Citation
Histology and histopathology, Vol. 28, n.º 5 (2013)
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