Publication: Metallic gold treatment reduces proliferation of inflammatory cells, increases expression of VEGF and FGF, and
stimulates cell proliferation in the subventricular
zone following experimental traumatic brain injury
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Date
2009
Authors
Østergaard Pedersen, Mie ; Larsen, Agnete ; Sonne Pedersen, Dan ; Stoltenberg, Meredin ; Penkowa, Milena
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Traumatic brain injury represents a leading
cause of morbidity in young individuals and there is an
imperative need for neuroprotective treatments limiting
the neurologic impairment following such injury. It has
recently been demonstrated that bio-liberated gold ions
liberated from small metallic gold implants reduce
inflammation and neuronal apoptosis, while generating
an increased neuronal stem cell response following focal
brain damage. In this study mice were subjected to a
unilateral traumatic cryo-lesion with concomitant
injection of 25-45 μm gold particles near the lesion.
Placebo-treated mice subjected to cryo-lesion served as
controls. The effects of gold-treatment were investigated
by examining gold-induced growth factor expression
(VEGF and FGF) in the first two weeks after the insult,
and the extent of the neurostimulatory effect of gold was
explored by comparing cell proliferation in the
subventricular zone as judged by immunohistochemical staining for CDC47. Vimentin staining revealed a
decrease in activated microglia and a transient
astrogliosis in response to the gold liberation. Moreover,
gold ions significantly increase the expression of VEGF
and FGF following trauma and a significant increase in
cell proliferation in both the ipsilateral and the
contralateral subventricular zone was found in response
to gold-treatment. In conclusion: we confirmed the
previously demonstrated anti-inflammatory effect of bioliberated
gold ions, and further show that metallic gold increases growth factor expression and adult neurogenesis.
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