Publication: Biocompati bility and osteoconductivity of the pyrost bone substitutes
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Date
1997
Authors
Tsuang, Y.H. ; Lin, F.H. ; Tai, H.C. ; Sun, J.S. ; Liu, H.C. ; Hang, Y. S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The purpose of this study was to re-evaluate
the bone regeneration power and the in vitro
biocompatibility of the Pyrost bone substitute. Twentyfour
adult New Zealand White rabbits were used. Bony
defect over both iliac crest and mid-diaphyseal portion
of the ulna bone were created. Appropriate sized-block
of Pyrost bone substitute were implanted. Four of the
animals were killed at each postoperative month to
evaluate its bone regeneration power by histologic study.
The Pyrost bones were co-cultured with osteoblasts to
evaluate its biocompatibility. The results showed that
Pyrost bone substitute was quite stable and incorporated
well with active bone regeneration. The Pyrost heal
better at the iliac crest than at the ulnar defect. The
Pyrost was compatible to the osteoblasts. Osteoblasts
had successfully seeded and mitotically expanded on the
porous surface of the Pyrost bone graft. The result
showed that Pyrost bone obviously exerts an intense
stimulus on osteo-regeneration in the presence of
osteoblasts. We consider Pyrost to be an altemate to the
conventional preserved allografts that is occasionally
necessary.
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