Publication: Contribution of the proximal and distal nerve stumps
to peripheral nerve regeneration in silicone chambers
Authors
Díaz-Flores, Lucio ; Gutiérrez, Ricardo ; Varela, H. ; Evora, P. ; Valladares, Francisco ; Rodríguez, M. ; Rancel, N. ; Álvarez-Argüelles, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The specific contnbution of the proximal and
distal neme stumps across an 8 mm gap within silicone
chamber regeneration models was studied. For this,
proximal and distal (Group A), distal and distal (Group
B) and proximal and proximal (Group C) neme stumps
were placed in opposite ends of silicone chambers. In al1
the groups, a tissue cable forms between the nerve
stumps, demonstrating that, without distinction,
proximal or distal stumps can stimulate the growth of
other proximal or distal stumps. Furthermore, in Group
B, the newly formed pseudo-nerve, in the absence of
regenerating axons, contains a number of Schwann cells
significantly similar to Group A, which confirms that
proliferation and migration of Schwann cells do not
require axonal presence or contact. Likewise, the
findings demonstrate that, with the exception of the
axons, the distal stump contributes to the peripheral
nerve regeneration in the same way as the proximal
stump. Finally, when proximal stumps are placed in both
the opposite ends of the silicone chamber, Schwann cells
and regenerating axons grow into the chamber gap from
both inserts, and myelination also proceeds from both
ends to the centre ofthe chambers.
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