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Cutillas Tolín, Ana

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Cutillas Tolín, Ana
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Universidad de Murcia. Departamento de Ciencias Sociosanitarias
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    Epidemiología nutricional y calidad seminal. Análisis de la composición de la dieta y su asociación con la calidad espermática.
    (2013-10-03) Cutillas Tolín, Ana; Torres Cantero, Alberto Manuel; López Espín, José Juan; Mendiola Olivares, Jaime; Mínguez Alarcón, Lidia; Facultad de Medicina
    Antecedentes/ Objetivos Desde los últimos cincuenta años la calidad seminal ha disminuido de forma progresiva. Nuestro objetivo es investigar si la calidad seminal en hombres jóvenes está asociada con la dieta. Material y Métodos Este estudio transversal comprende a 215 jóvenes universitarios de Murcia. Se evaluó la dieta a través de un cuestionario de frecuencia alimentaria. Se identificaron patrones dietéticos mediante análisis factorial, de clústers e índices de calidad de la dieta. Se estudió su relación con la calidad seminal. Resultados Un patrón dietético “mediterráneo” se asocia con mejores recuentos espermáticos y de espermatozoides móviles. No se observó una asociación lineal entre la calidad seminal y los índices aMED y AHEI. La movilidad espermática total estaba relacionada positivamente con altas ingestas de los ácidos grasos α-linolénico (ALA) y esteárico. Conclusión La calidad seminal de la población joven y sana podría verse influenciada por los patrones de ingesta alimentaria. Palabras clave: ácidos grasos, calidad seminal, dieta, dieta Mediterránea, índice AHEI, índice aMED, ingesta alimentaria, patrones dietéticos. Abstract Introduction Over the past fifty years there have been evidences of a decline in semen quality. This study investigates whether semen quality in young men is associated with diet. Materials and Methods This cross sectional study included 215 university students from Murcia. Diet was assessed through a food frequency questionnaire. We identified dietary patterns using factor and cluster analysis and diet quality indexes. We evaluated its relationship with semen quality. Results “Mediterranean” pattern was associated with higher sperm counts and mobile spermatozoa counts. A lineal association between aMED and AHEI indexes was not observed. Total motility was related to higher intakes of fatty acids α-linolenic (ALA) and stearic. Conclusion The semen quality in healthy young population could be influenced by patterns of dietary intake Keywords: aMED index, AHEI index, dietary intake, dietary patterns, fatty acids, Mediterranean diet, semen quality.
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    Fat intake pattern in women with polycystic ovary syndrome.
    (Elsevier, 2022-01) Navarro Lafuente, Fuensanta; Arense Gonzalo, Julián Jesús; Sánchez Ferrer, María Luisa; Prieto Sánchez, María Teresa; Cutillas Tolín, Ana; Mendiola Olivares, Jaime; Adoamnei, Evdochia; Torres Cantero, Alberto Manuel; Gazabat-Barbado, Esteban; Vioque López, Jesús; Ciencias Sociosanitarias
    Research question: Do women with polycystic ovary syndrome (PCOS) have a different fat intake pattern to women without PCOS? Design: Case–control study of 276 women between 20 and 35 years old from the Murcia region of Spain. Cases (n = 121) attended the Department of Gynaecology and Obstetrics of the University Clinical Hospital and were diagnosed with PCOS using Rotterdam criteria. Controls (n = 155) were women without PCOS attending the gynaecological outpatient clinic for routine gynaecological examinations. Data from clinical, gynaecological and analytical examinations were collected, including a food frequency questionnaire. Associations between fat intake and presence of PCOS and its phenotypes were examined using multiple logistic regression, adjusting for potential confounding factors. Results: Although no association was found between fatty acid intake and PCOS, significant associations were observed for some PCOS phenotypes. The PCOS phenotype characterized by hyperandrogenism + oligo/amenorrhoea + polycystic ovarian morphology (‘H+O+POM’) was significantly associated with a higher intake of polyunsaturated fat (odds ratio [OR] 4.0; 95% confidence interval [CI] 1.1–14.2; fourth quartile of highest intake [Q4] versus lowest intake quartile as reference [Q1]) and omega-6 fatty acids (OR 3.5; 95% CI 1.01–12.4; Q3 versus Q1). The ‘H+O’ phenotype was positively associated with saturated fat intake (OR 6.9; 95% CI 1.1–41.6; Q4 versus Q1). Conclusion: This exploratory study suggests that higher intakes of specific fatty acids are related to some PCOS phenotypes although no association was found for PCOS on a global basis. It is recommended that studies with larger sample size be performed to further explore these associations, thus contributing to establishing recommendations about fat intake adapted to different PCOS phenotypes.
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    Maternal non-compliance with recommended folic acid supplement use alters global DNA methylation in cord blood of newborns: a cohort study
    (Elsevier, 2024) Morales Bartolomé, Eva; Prieto Sánchez, María Teresa; Mendiola Olivares, Jaime; Cutillas Tolín, Ana; Adoamnei, Evdochia; Valera-Gran, Desiree; Santaella-Pascual, Marina; Suárez Martínez, Clara; Vioque, Jesús; Castaños, María Jesús; Castillo, Eva del; García-Marcos Álvarez, Luis Vicente; Tecnología de Alimentos, Nutrición y Bromatología; Facultad de Veterinaria
    Background & aims: Prenatal folate exposure may alter epigenetic marks in the offspring. We aimed to evaluate associations between prenatal exposure to folic acid (FA) in preconception and in utero with cord blood DNA methylation in long interspersed nuclear element 1 (LINE-1) and Alu short interspersed nuclear elements (SINEs) as markers of global DNA methylation levels. Methods: Data come from 325 motherechild pairs participating in the Nutrition in Early Life and Asthma (NELA) birth cohort (2015e2018). Pregnant women were asked about supplement use, including brand name and dose, one month before pregnancy (preconception) and through the trimesters of pregnancy. Maternal dietary folate intake was assessed using a validated food frequency questionnaire with additional questions for FA supplement use. Folate serum levels were measured in mothers at 24 weeks of gestation and in cord blood of newborns. DNA methylation was quantitatively assessed by bisulfite pyrosequencing on 5 LINE-1 and 3 Alu different elements. Associations were estimated using multivariable linear regression models. Results: A reduction in methylation levels of LINE-1 in newborns was associated with the use of FA supplements below the recommended doses (<400 ug/day) during preconception ( 0.50; 95% CI:  0.91,  0.09; P ¼ 0.016), and from preconception up to 12 weeks of gestation ( 0.48; 95% CI:  0.88,  0.08; P ¼ 0.018). Maternal use of FA supplements above the tolerable upper intake level of 1000 ug/day from preconception until 12 weeks of gestation was also related to lower methylation in LINE-1 at birth ( 0.77; 95% CI:  1.52,  0.02; P ¼ 0.044). Neither FA supplement use after 12 weeks of gestation nor maternal total folate intake (diet plus supplements) were associated with global DNA methylation levels at birth.
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    Are Dietary Indices Associated with Polycystic OvarySyndrome and Its Phenotypes? A Preliminary Study
    Cutillas Tolín, Ana; Arense Gonzalo, Julián Jesús; Mendiola Olivares, Jaime; Adoamnei, Evdochia; Navarro Lafuente, Fuensanta; Sánchez Ferrer, María Luisa; Prieto Sánchez, María Teresa; Torres Cantero, Alberto Manuel; Carmona Barnosi, Ana; Vioque López, Jesús; Ciencias Sociosanitarias
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