Mendiola Olivares, Jaime

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Mendiola Olivares, Jaime

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Mendiola Olivares, Jaime

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Universidad de Murcia. Departamento de Ciencias Sociosanitarias

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Open Access
Protocol: Survey responses to estimate the association between Covid-19 sources of information, beliefs, and vaccination rates
(2022-09) Moreno-Llamas, Antonio; Devine, Beth; Cruz Sánchez, Ernesto de la; Mendiola Olivares, Jaime; García Mayor, Jesús; Torres Cantero, Alberto Manuel; Actividad Física y Deporte
Open Access
Association between Covid-19 sources of information, beliefs, and vaccination rates: an EU-wide survey.
(Oxford University Press, 2023-07-14) Moreno Llamas, Antonio; Devine, Emily Beth; Cruz Sánchez, Ernesto de la; Mendiola Olivares, Jaime; García Mayor, Jesús; Torres Cantero, Alberto Manuel; Ciencias Sociosanitarias
Background: Misinformation hampers vaccine uptake. The European Union (EU) employed a coordinated effort to curb misinformation during the Covid-19 pandemic. In this context, we investigated relationships between sources of information, vaccine safety/effectiveness, satisfaction with government vaccination strategy, and vaccination intent. Methods: We used cross-sectional survey data (May 2021) from Flash Eurobarometer 494, a populationadjusted dataset comprised of a representative sample of those 15 years from 27 EU nations. We employed a latent class analysis to create clusters of information sources as the independent variable and beliefs in vaccine safety/efficacy, satisfaction with government vaccination strategy, and vaccine intent as four outcome variables. We first estimated the association between source clusters and each of the first three outcomes separately. Then, using these three as intermediate variables, we employed structural equation modeling to estimate the relationship between sources and vaccine intent. We adjusted for individual and country-level variables. Results: Among 23 012 respondents, four clusters of information sources emerged: (1) national authorities/health professionals (n¼9602; 42%), (2) mostly health professionals (6184; 27%), (3) mixed (n¼1705; 17%) and (4) social media/family/ friends (n¼5524; 24%). Using cluster (3) as the referent, we found decreasing odds of beliefs in vaccine safety/effectiveness, satisfaction and vaccine intent across clusters (1), (2) and (4), respectively. Demographics played a role. Conclusion: In the context of the Covid pandemic, these results provide the first EU-wide estimates of the association between sources of information about vaccine safety/effectiveness, satisfaction and vaccine intent. The coordinated approach promulgated by the EU to minimize misinformation provides a model for managing future pandemics.
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Does the anogenital distance change across pregnancy?
(Elsevier, 2020-05-25) Sánchez Ferrer, María Luisa; Arense Gonzalo, Julián Jesús; Prieto Sánchez, María Teresa; Alfosea-Marhuenda, Emilia; Gómez-Carrascosa, Inmaculada; Iniesta, Miguel A.; Mendiola Olivares, Jaime; Torres Cantero, Alberto Manuel; Ciencias Sociosanitarias; Facultad de Farmacia
Research question: Does the length of the anogenital distance (AGD), an anthropometric biomarker of fetal androgen exposure, change across pregnancy? It has been suggested that AGD remains stable during adulthood with no changes across the menstrual cycle. No studies, however, have been carried out during pregnancy, during which women are exposed to important hormonal and anthropometric variations. Design: A cohort study of 186 singleton pregnant women recruited in the first trimester of pregnancy. Measurements from the anterior clitoral surface to the upper verge of the anus (AGDAC), and from the posterior fourchette to the upper verge of the anus (AGDAF) and body mass index (BMI) were obtained in each trimester. Generalized linear model for repeated measures was carried out to assess differences in AGDs and BMI across the three trimesters of the pregnancy. Results: In crude analyses, AGDAC was progressively and significantly longer as the pregnancy developed (first trimester: 87.69 ± 13.14mm; second trimester: 89.69 ± 13.47mm; third trimester: 91.95 ± 13.25 mm; P < 0.001), whereas AGDAF did not significantly change throughout pregnancy (first trimester: 28.37 ± 6.94 mm; second trimester: 28.09 ± 7.66 mm; third trimester: 28.94 ± 6.7 mm). In the multivariable mixed-effect models for fixed effect (trimester) and time-covariate (BMI), AGDs did not show significant associations with trimesters of pregnancy when BMI was included in the model. Conclusions: Our results suggest that AGDAF and AGDAC, when adjusted by BMI, do not change throughout gestation despite maternal anthropometric variations during pregnancy. AGDAF may be a meaningful measurement at any time during pregnancy without considering BMI. Therefore, maternal AGDAF may be used as a prenatal biomarker of the mother's in-uteru hormonal exposure even during pregnancy.
Open Access
Is maternal use of Paracetamol during pregnancy associated with anogenital distance in male newborns? The results from the NELA Birth Cohort
(MDPI, 2021-06-11) Navarro Lafuente, Fuensanta; Arense Gonzalo, Julián Jesús; Adoamnei, Evdochia; Prieto Sánchez, María Teresa; Sánchez Ferrer, María Luisa; García-Marcos Álvarez, Luis Vicente; Morales Bartolomé, Eva; Mendiola Olivares, Jaime; Torres Cantero, Alberto Manuel; Ciencias Sociosanitarias
Paracetamol is the one of the most commonly used medications during pregnancy. However, its potential antiandrogenic effect has been suggested. The objective of this study was to evaluate associations between maternal paracetamol use during pregnancy and anogenital distance (AGD) in male newborns from a Spanish birth cohort. The study included two hundred and seventy-seven mother-male child pairs with self-reported paracetamol use and frequency during each trimester of pregnancy. AGD measurements were taken employing standardized methods. The associations between maternal paracetamol use and AGD measures were evaluated using linear regression models, adjusting for potential confounders and covariates. Overall, 61.7% of pregnant women consumed paracetamol at any time of pregnancy with an average of 9.43 (SD = 15.33) days throughout pregnancy. No associations between the maternal use of paracetamol or its frequency and AGD measures among different trimesters or during the whole pregnancy were found in the adjusted final models. A non-differential misclassification error may have occurred—the recall of paracetamol intake independent of AGD measurements—introducing bias towards the null hypothesis. Nevertheless, the current evidence suggests that paracetamol might have a potential antiandrogenic effect especially in the early stages of fetal development. Thus, it would be highly recommendable to pursue further studies to elucidate the potential effects of paracetamol in human perinatal health and its use among pregnant women.
Open Access
Maternal urinary concentrations of bisphenol A during pregnancy are associated with global DNA methylation in cord blood of newborns in the “NELA” birth cohort
(Elsevier, 2022-06-03) Navarro Lafuente, Fuensanta; Adoamnei, Evdochia; Arense Gonzalo, Julián Jesús; Prieto Sánchez, María Teresa; Sánchez Ferrer, María Luisa; Parrado, Antonio; Fernández, Mariana F.; Suarez, Beatriz; López Acosta, Antonia; Sánchez Guillamón, Antonio; García-Marcos Álvarez, Luis Vicente; Morales Bartolomé, Eva; Mendiola Olivares, Jaime; Torres Cantero, Alberto Manuel; NELA Study group; Ciencias Sociosanitarias
Endocrine disrupting chemicals (EDCs) set a public health risk through disruption of normal physiological processes. The toxicoepigenetic mechanisms of developmental exposure to common EDCs, such as bisphenol A (BPA), are poorly known. The present study aimed to evaluate associations between perinatal maternal urinary concentrations of BPA, bisphenol S (BPS) and bisphenol F (BPF) and LINE-1 (long interspersed nuclear elements) and Alu (short interspersed nuclear elements, SINEs) DNA methylation levels in newborns, as surrogate markers of global DNA methylation. Data come from 318 mother-child pairs of the `Nutrition in Early Life and Asthma´ (NELA) birth cohort. Urinary bisphenol concentration was measured by dispersive liquid–liquid microextraction and ultrahigh performance liquid chromatography with tandem mass spectrometry detection. DNA methylation was quantitatively assessed by bisulphite pyrosequencing on 3 LINEs and 5 SINEs. Unadjusted linear regression analyses showed that higher concentration of maternal urinary BPA in 24th week's pregnancy was associated with an increase in LINE-1 methylation in all newborns (p = 0.01) and, particularly, in male newborns (p = 0.03). These associations remained in full adjusted models [beta = 0.09 (95 % CI = 0.03; 0.14) for all newborns; and beta = 0.10 (95 % CI = 0.03; 0.17) for males], including a non-linear association for female newborns as well (p-trend = 0.003). No associations were found between maternal concentrations of bisphenol and Alu sequences. Our results suggest that exposure to environmental levels of BPA may be associated with a modest increase in LINE-1 methylation -as a relevant marker of epigenomic stability- during human fetal development. However, any effects on global DNA methylation are likely to be small, and of uncertain biological significance.
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Fat intake pattern in women with polycystic ovary syndrome.
(Elsevier, 2022-01) Navarro Lafuente, Fuensanta; Arense Gonzalo, Julián Jesús; Sánchez Ferrer, María Luisa; Prieto Sánchez, María Teresa; Cutillas Tolín, Ana; Mendiola Olivares, Jaime; Adoamnei, Evdochia; Torres Cantero, Alberto Manuel; Gazabat-Barbado, Esteban; Vioque López, Jesús; Ciencias Sociosanitarias
Research question: Do women with polycystic ovary syndrome (PCOS) have a different fat intake pattern to women without PCOS? Design: Case–control study of 276 women between 20 and 35 years old from the Murcia region of Spain. Cases (n = 121) attended the Department of Gynaecology and Obstetrics of the University Clinical Hospital and were diagnosed with PCOS using Rotterdam criteria. Controls (n = 155) were women without PCOS attending the gynaecological outpatient clinic for routine gynaecological examinations. Data from clinical, gynaecological and analytical examinations were collected, including a food frequency questionnaire. Associations between fat intake and presence of PCOS and its phenotypes were examined using multiple logistic regression, adjusting for potential confounding factors. Results: Although no association was found between fatty acid intake and PCOS, significant associations were observed for some PCOS phenotypes. The PCOS phenotype characterized by hyperandrogenism + oligo/amenorrhoea + polycystic ovarian morphology (‘H+O+POM’) was significantly associated with a higher intake of polyunsaturated fat (odds ratio [OR] 4.0; 95% confidence interval [CI] 1.1–14.2; fourth quartile of highest intake [Q4] versus lowest intake quartile as reference [Q1]) and omega-6 fatty acids (OR 3.5; 95% CI 1.01–12.4; Q3 versus Q1). The ‘H+O’ phenotype was positively associated with saturated fat intake (OR 6.9; 95% CI 1.1–41.6; Q4 versus Q1). Conclusion: This exploratory study suggests that higher intakes of specific fatty acids are related to some PCOS phenotypes although no association was found for PCOS on a global basis. It is recommended that studies with larger sample size be performed to further explore these associations, thus contributing to establishing recommendations about fat intake adapted to different PCOS phenotypes.
Open Access
Maternal non-compliance with recommended folic acid supplement use alters global DNA methylation in cord blood of newborns: a cohort study
(Elsevier, 2024) Morales Bartolomé, Eva; Prieto Sánchez, María Teresa; Mendiola Olivares, Jaime; Cutillas Tolín, Ana; Adoamnei, Evdochia; Valera-Gran, Desiree; Santaella-Pascual, Marina; Suárez Martínez, Clara; Vioque, Jesús; Castaños, María Jesús; Castillo, Eva del; García-Marcos Álvarez, Luis Vicente; Tecnología de Alimentos, Nutrición y Bromatología; Facultad de Veterinaria
Background & aims: Prenatal folate exposure may alter epigenetic marks in the offspring. We aimed to evaluate associations between prenatal exposure to folic acid (FA) in preconception and in utero with cord blood DNA methylation in long interspersed nuclear element 1 (LINE-1) and Alu short interspersed nuclear elements (SINEs) as markers of global DNA methylation levels. Methods: Data come from 325 motherechild pairs participating in the Nutrition in Early Life and Asthma (NELA) birth cohort (2015e2018). Pregnant women were asked about supplement use, including brand name and dose, one month before pregnancy (preconception) and through the trimesters of pregnancy. Maternal dietary folate intake was assessed using a validated food frequency questionnaire with additional questions for FA supplement use. Folate serum levels were measured in mothers at 24 weeks of gestation and in cord blood of newborns. DNA methylation was quantitatively assessed by bisulfite pyrosequencing on 5 LINE-1 and 3 Alu different elements. Associations were estimated using multivariable linear regression models. Results: A reduction in methylation levels of LINE-1 in newborns was associated with the use of FA supplements below the recommended doses (<400 ug/day) during preconception ( 0.50; 95% CI: 0.91, 0.09; P ¼ 0.016), and from preconception up to 12 weeks of gestation ( 0.48; 95% CI: 0.88, 0.08; P ¼ 0.018). Maternal use of FA supplements above the tolerable upper intake level of 1000 ug/day from preconception until 12 weeks of gestation was also related to lower methylation in LINE-1 at birth ( 0.77; 95% CI: 1.52, 0.02; P ¼ 0.044). Neither FA supplement use after 12 weeks of gestation nor maternal total folate intake (diet plus supplements) were associated with global DNA methylation levels at birth.
Open Access
Are Dietary Indices Associated with Polycystic OvarySyndrome and Its Phenotypes? A Preliminary Study
Cutillas Tolín, Ana; Arense Gonzalo, Julián Jesús; Mendiola Olivares, Jaime; Adoamnei, Evdochia; Navarro Lafuente, Fuensanta; Sánchez Ferrer, María Luisa; Prieto Sánchez, María Teresa; Torres Cantero, Alberto Manuel; Carmona Barnosi, Ana; Vioque López, Jesús; Ciencias Sociosanitarias