Parrilla Reverter, Guillermo

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Parrilla Reverter, Guillermo

Universidad de Murcia. Departamento de Medicina

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Time-course of the retinal nerve fibre layer degeneration after complete intra-orbital optic nerve transection or crush: a comparative study
(Elsevier, 2009-11-23) Parrilla Reverter, Guillermo; Agudo Barriuso, Marta; Nadal-Nicolás, Francisco Manuel; Jiménez López, Manuel; Salinas Navarro, Manuel Ángel; Sobrado Calvo, Paloma; Bernal Garro, José M.; Villegas Pérez, Maria Paz; Vidal Sanz, Manuel; Alarcón Martínez, Luis; Oftalmología, Optometría, Otorrinolaringología y Anatomía Patológica; Facultades de la UMU::Facultad de Medicina
We examined qualitatively and quantitatively in adult rat retinas the temporal degeneration of the nerve fibre layer after intra-orbital optic nerve transection (IONT) or crush (IONC). Retinal ganglion cell (RGC) axons were identified by their heavy neurofilament subunit phosphorylated isoform (pNFH) expression. Optic nerve injury induces a progressive axonal degeneration which after IONT proceeds mainly with abnormal pNFH-accumulations in RCG axons and after IONC in RGCs somas and dendrites. Importantly, this aberrant pNFH-expression pattern starts earlier and is more dramatic after IONT than after IONC, highlighting the importance that the type of injury has on the time-course of RGC degeneration.

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