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Marín Parra, Claudia

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Marín Parra, Claudia
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Biología Celular e Histología
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    Biomarker-based assessment of somatostatin-6 immunomodulation in gilthead Seabream: From serum proteins to skin mucus enzymes
    (0022-10-20) Jose Carlos Campos Sánchez; Cristóbal Espinosa-Ruiz; Francisco A. Guardiola; Esteban Abad, María de los Ángeles; Guardiola Abellán, Francisco Antonio; Marín Parra, Claudia; Biología Celular e Histología
    This study evaluated the immunomodulatory role of somatostatin-6 (SST6) in gilthead seabream (Sparus aurata) using a validated inflammation model induced by λ-carrageenan and a comprehensive panel of serum and skin mucus biomarkers. SST6 was administered at 1 nM and 2 nM, and its effects were assessed in these matrices. The λ-carrageenan model triggered a local inflammatory response with reduced peroxidase, esterase, and protease activities in skin mucus, consistent with the resolution phase of innate immunity. SST6 at 1 nM enhanced serum complement activity without affecting acute-phase proteins, suggesting reinforcement of basal immune surveillance in the host. When combined with λ-carrageenan, SST6 promoted an increase in serum immunoglobulin levels and a selective shift in proteinogram fractions (α2-globulin), while further decreasing the oxidative and proteolytic activities in skin mucus. Correlation analysis revealed the coordinated regulation of key mucosal enzymes, reinforcing the functional integration of local immune responses. These results indicate that SST6 facilitates an early transition from innate to adaptive immunity while preserving the integrity of the mucosal barrier. Furthermore, this study provides the first evidence of complement activation by SST6 in fish and highlights the value of integrating biomarker-based tools to monitor immunophysiological responses and test bioactive compounds in aquaculture research.
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    Report of "Host Defense Peptide Hepcidin 1 and Iron Overload Differentially Modulate Energy, Lipid, and Hepatic–Biliary Metabolic Pathways in Gilthead Seabream (Sparus aurata) Blood"
    (2025) Laura García-Navarro; Serna Duque, John Alberto; Marín Parra, Claudia; Esteban Abad, María de los Ángeles; Esteban Abad, María de los Ángeles; Biología Celular e Histología; Esteban Abad, María de los Ángeles; Facultades de la UMU::Facultad de Biología
    Hepcidin 1 (HDP, antimicrobial and iron regulator peptide) and iron overload are relevant in aquaculture, but their in vivo physiological effects in healthy fish are poorly characterized. This study evaluated how intraperitoneal injections of hepcidin 1, iron (iron-dextran), and a sequential treatment (iron and hepcidin 1) modulate the blood metabolome of gilthead sea bream (Sparus aurata) at 10 days, due to their adaptive role in response to systemic changes. Multivariate analyses showed metabolomic alterations in all three situations, although weak at 10 days; in the iron→hepcidin 1 group, the separation in PCA was not significant (P=0.247), suggesting overlap or absence of unidirectional shift. In all three treatments, 15 chemical superclasses were conserved (predominance of lipids), indicating quantitative reorganization. There was an activation of energy metabolism coupled with immune response, involving lipids, fatty acids, acyl-CoA/acylcarnitines, and signals from one-carbon metabolism (folate/serine/methionine) connected to NAD(H)/NADP(H) and redox balance, although several associations lost robustness (non-significant FDR), consistent with a return to homeostasis. Hepcidin 1 was associated with increased adenosine, Lys-Glu-Leu tripeptide, dodecanoylcarnitine and phosphoethanolamines/phosphocholines (LysoPE/PE/LysoPC), along with a decrease in exogenous compounds (e.g., erythromycin C, harzianopyridone), suggesting modulation of the gut–microbiota–barrier axis or hepatic-biliary clearance. Iron overload induced reprogramming compatible with reactive oxygen species management (increase in catalposide and L-NIL/L-NILL-type metabolites), lipid remodeling (decrease in PC/PE/PS, cholesterol esters and triglycerides), and greater mitochondrial mobilization of fatty acids (increase in linoleylcarnitine), without clear markers of peroxidation, liver damage or inflammation; herbicides (bensulfuron/sulfometuron methyl) were also reduced. In the iron and hepcidin 1 group, metabolites pointed to three axes: β-oxidation/fatty acid transport, phospho-/sphingolipid remodeling, and hepatic-biliary involvement with possible microbiota alteration. In conclusion, hepcidin 1 and iron modulate energy and lipid metabolism in gilthead sea bream blood, providing biomarkers and a framework for interpreting immunometabolic adaptations in aquaculture, although targeted validation of annotations and higher temporal resolution are required.
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    Gene expression raw data of the work entitlled: "evolution of a gilthead sea bream (Sparus aurata L.) caudal fin skin explant"
    Albaladejo-Riad, Nora; García-Álvarez, Miguel Ángel; Cuesta Peñafiel, Alberto; Esteban Abad, María de los Ángeles; Marín Parra, Claudia; Biología Celular e Histología
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    Metabolomic profiling of the serological response to a hepcidin 1 injection in gilthead seabream (Sparus aurata)
    García Navarro, Laura; Esteban Abad, María de los Ángeles; Marín Parra, Claudia; Biología Celular e Histología
    Datos obtenidos mediante HILIC y RP con ESI positiva y negativa.
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    Dataset used for Report of "Proteomic changes induced by hepcidin 1 injection in brain and skin of gilthead seabream (Sparus aurata)"
    (2025) Laura García-Navarro; Serna Duque, John Alberto; Marín Parra, Claudia; M. Ángeles Esteban; Biología Celular e Histología; M. Ángeles Esteban
    The present study investigated the effects of hepcidin 1 (Hamp1) on the proteome of brain and skin of gilthead seabream (Sparus aurata). Hepcidin 1, a host defense peptide with antimicrobial and immunomodulatory functions, was inyected intraperitoneally at a dose of 25 μM. Proteomic analyses of brain and skin samples were performed using HPLC-MS/MS at 4 and 10 days post-injection. Data processing and analysis revealed significant alterations in protein expression profiles in both tissues. In the brain, hepcidin 1 injection upregulated proteins involved in DNA repair, myelin sheath structure, and extracellular matrix remodeling at 4 days, while at 10 days, changes were observed in proteins involved in endoplasmic reticulum calcium channels, Golgi apparatus glycosylation, and cytoskeletal dynamics. Skin samples exhibited increased expression of proteins related to endoplasmic reticulum stress response, cell adhesion, and vesicular trafficking at 4 days. At 10 days, skin proteome alterations indicated a metabolic shift towards enhanced glycolysis, oxidative stress adaptation, and cytoskeletal remodeling. These findings suggest that hepcidin 1 induces tissue-specific and time-dependent proteomic changes in gilthead seabream, potentially modulating immune responses, energy metabolism, and cellular adaptation processes. Further research is needed to elucidate the functional implications of these proteomic alterations and their potential applications in aquaculture health management.
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    Reduced hepcidin 1 of gilthead seabream (Sparus aurata): Immunomodulatory effects and implications in iron homeostasis
    (2026) Marín Parra, Claudia; García, Laura; Serna Duque, John Alberto; Ortiz García, María; Martínez López, Salvadora; R. Coxon, Christopher; Espinosa Ruiz, Cristóbal; Esteban Abad, María de los Ángeles; Esteban Abad, María de los Ángeles; Biología Celular e Histología; María Ángeles Esteban Abad; Facultades de la UMU::Facultad de Biología
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    Data for compounds included in the article: "Exploring the multifaceted effects of dietary encapsulated piscidin 1 on gilthead seabream (Sparus aurata): from immunomodulation to muscle quality"
    (2026-05-22) Claudia Marín Parra; Marín Parra, Claudia; Espinosa Ruiz, Cristóbal; Coxon, Christopher R.; Esteban Abad, María de los Ángeles; María Ángeles Esteban Abad; Biología Celular e Histología; María Ángeles Esteban Abad
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